adverse against the grain against the tide against the wind alienated antagonistic antagonistically antiestablishment at cross-purposes at daggers at daggers drawn at issue at odds at odds with at variance at variance with at war with athwart breakaway conflicting contra contrariwise contrary counter counter to counter-culture counteractive counteractively cross detrimental differing difficult disagreeing dissentient dissenting dissident eyeball-to-eyeball hard harmful hostile in confrontation in hostile array in opposition to inimical miserable nonconforming not easy opposed opposing opposingly opposite recusant rigorous sectarian sectary sinister stressful troublesome troublous trying underground unfavorable untoward up in arms with crossed bayonets wretched